Histidine Titration Curve: Unraveling Protonation And Ionization
The titration curve of histidine, an amino acid with a unique three-pKa behavior, reveals important insights into its protonation states and ionization characteristics. The curve exhibits three distinct equivalence points corresponding to the protonation of the amino, imidazole, and carboxyl groups. At low pH, histidine primarily exists as a cation with a protonated amino group, … Read more